High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes
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چکیده
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High Density Lipoprotein: A Therapeutic Target in Type 2 Diabetes
High density lipoproteins (HDLs) have a number of properties that have the potential to inhibit the development of atherosclerosis and thus reduce the risk of having a cardiovascular event. These protective effects of HDLs may be reduced in patients with type 2 diabetes, a condition in which the concentration of HDL cholesterol is frequently low. In addition to their potential cardioprotective ...
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15 صفحه اولPTPN2, a potential therapeutic target for type 1 diabetes?
W e read with great interest the article by Rheinheimer and cols. (1), showing that four hundred and eighty six patients with type 1 diabetes (T1D) and 484 nondiabetic subjects were conducted to discuss the rs1893217 (T/C) polymorphism in protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) gene for T1D from Southern Brazil, by which the C allele was observed in 14.5% of the T1D patie...
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Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...
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Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have T2D, and the International Diabetes Federation projects that this number will increase to nearly 600 million by 2035. There is a great need for more effective treatments for maintaining glucose homeostasis and improving...
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ژورنال
عنوان ژورنال: Aging
سال: 2021
ISSN: 1945-4589
DOI: 10.18632/aging.202714